p38 MAPK

MAPK

p38 MAPK

p38 MAPK Isoform Specific Products:

p38 MAPK Related Products (530)
Recombinant Proteins (3)
Antibodies (20)
p38 MAPK Isoform Comparison

By Effects:	Control (1) Inhibitors (387) Agonists (3) Degrader (1) Activators (85) Modulators (5) p53 Inhibitor (1) Inducers (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-172409

CB1R antagonist 2	Inhibitor
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models.

HY-172209

PPIA-IN-1	Inhibitor
PPIA-IN-1 (Compound 20b) is the inhibitor for peptidylprolyl isomerase A (PPIA) with a K_D of 0.52 μM. PPIA-IN-1 exhibits antiproliferative activity in a variety of cancer cell lines (IC₅₀ for HCT116 is 0.69 μM), arrests the cell cycle at G0/G1 phase, and exhibits anti-metastatic effect in cell HCT116. PPIA-IN-1 increases ROS, causes DNA damage, ER stress and mitochondrial dysfunction, inducing apoptosis in HCT116 through MAPK pathway. PPIA-IN-1 exhibits antitumor activity in mouse CT26 xenograft models.

HY-W018197R

2-Phenylacetamide (Standard)	Inhibitor
2-Phenylacetamide (Standard) is the analytical standard of 2-Phenylacetamide. This product is intended for research and analytical applications. 2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active.

HY-108642A

AMG-548 hydrochloride	Inhibitor
AMG-548 hydrochloride, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 hydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM). AMG-548 hydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.

HY-N0755R

Rhoifolin (Standard)	Activator
Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.

HY-101268

CHMFL-ABL-053	Inhibitor
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC₅₀ values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively.

HY-15509

Semapimod
Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders.

HY-111214

K-14585	Inhibitor
K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca²⁺ mobilisation in primary human keratinocytes.

HY-N7255R

Cycloartenol (Standard)	Inhibitor
Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development.

HY-10261R

Afatinib (Standard)	Inhibitor
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

HY-76006R

3-Hydroxybenzaldehyde (Standard)	Inhibitor
3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].

HY-172406

MAPK-IN-4	Inhibitor
MAPK-IN-4 (Compound c1) is an orally active anti-inflammatory agent. MAPK-IN-4 can inhibit the expression and release of pro-inflammatory cytokines IL-6 and TNF-α induced by LPS (HY-D1056). MAPK-IN-4 can bind to IRAK4 and exert its anti-inflammatory effect by inhibiting the MAPK pathway.

HY-N9955

Isonardosinone	Inhibitor
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056)-induced BV2 microglia, exhibits anti-inflammatory activity.

HY-N13294

Cernuumolide J	Activator
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC₅₀ value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.

HY-N0202R

Atractylenolide II (Standard)	Activator
Atractylenolide II (Standard) is the analytical standard of Atractylenolide II. This product is intended for research and analytical applications. Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity.

HY-158334

NDs-IN-1	Inhibitor
(Neurodegenerative diseases) NDs-IN-1 (Compound 3g) inhibits the activities of key enzymes such as hBACE-1, hAChE and hMAO-B. NDs-IN-1 is a novel non-covalent multi-target inhibitor. NDs-IN-1 is mainly used in the study of neurodegenerative diseases.

HY-17007S

Saquinavir-d₉	Inhibitor
Saquinavir-d₉ (Ro 31-8959-d₉) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.

HY-N7128R

Flavanone (Standard)	Inhibitor
Flavanone (Standard) is the analytical standard of Flavanone. This product is intended for research and analytical applications. Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). lavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy.

HY-10403A

(aS)-PH-797804	Inhibitor
(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC₅₀ values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity.

HY-N2393S

Kukoamine B-d₅ dihydrochloride	Inhibitor
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .

Adezmapimod	p38, IC₅₀: 50 nM		p38β2, IC₅₀: 500 nM				99.96%
SB 202190		p38α, IC₅₀: 50 nM	p38β2, IC₅₀: 100 nM				99.89%
Doramapimod	p38 MAP kinase, Kd: 0.1 nM	p38α, IC₅₀: 38 nM	p38β, IC₅₀: 65 nM		p38δ, IC₅₀: 520 nM	p38γ, IC₅₀: 200 nM	99.98%
Adezmapimod hydrochloride	p38, IC₅₀: 50 nM		p38β2, IC₅₀: 500 nM				99.71%
Muramyl dipeptide	p38 MAPK						≥98.0%
Diprovocim	p38 MAPK						98.82%
Naporafenib		p38α, IC₅₀: 2.1 μM					99.86%
Ralimetinib dimesylate		p38α MAPK, IC₅₀: 5.3 nM	p38β MAPK, IC₅₀: 3.2 nM				99.94%
Neflamapimod		p38α, IC₅₀: 10 nM	p38β, IC₅₀: 220 nM				99.32%
Exarafenib	p38 MAPK						99.68%
Skatole	p38						99.97%
Esculin	p38 MAPK						99.47%
Talmapimod		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM				98.97%
p38 MAPK-IN-1	p38 MAPK, IC₅₀: 68 nM						99.58%
SB 202190 hydrochloride		p38α, IC₅₀: 50 nM	p38β2, IC₅₀: 100 nM				99.84%
Tpl2 Kinase Inhibitor 1	p38, IC₅₀: 180 μM						99.22%
Paris saponin VII	p38						99.96%
Broussonin E	p38 MAPK						98.18%
AMG-548 dihydrochloride		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM	99.91%
Semapimod tetrahydrochloride	p38 MAPK						98.43%
TAK-715		p38α, IC₅₀: 7.1 nM	p38β, IC₅₀: 200 nM		p38δ, IC₅₀: >10 μM	p38γ, IC₅₀: >10 μM	99.76%
Gossypetin	p38 MAP kinase						99.82%
Peimine	p38						99.43%
Dihydrocaffeic acid	p38 MAPK						99.65%
MAPK13-IN-1				MAPK13 (p38δ), IC₅₀: 620 nM			98.93%
Teneligliptin hydrobromide	p38 MAPK						99.99%
NF-κB/MAPK-IN-1	p38						98.42%
Pamapimod		p38α, IC₅₀: 14 nM p38α, Ki: 1.3 nM	p38β, IC₅₀: 480 p38β, Ki: 120 nM				99.92%
UM-164		p38α	p38β				99.15%
Cornuside	p38 MAP kinase						99.99%
SM-7368	p38 MAP kinase						99.77%
Ferulic acid methyl ester	p38						99.95%
EW-7195		p38α, IC₅₀: 1.5 μM					98.84%
Emprumapimod		p38α					99.04%
SR-318		p38α, IC₅₀: 5 nM	p38β, IC₅₀: 32 nM				99.89%
BMS-582949 hydrochloride		p38α MAPK, IC₅₀: 13 nM					98.90%
Isoliquiritin apioside	p38 MAPK						99.87%
MW-150		p38α, Ki: 101 nM					99.89%
MKK7-COV-9	p38 MAP kinase
N-Feruloyloctopamine	p38 MAPK						99.91%
R1487 Hydrochloride		p38α, Kd: 0.2 nM	p38β, Kd: 29 nM				99.33%
TA-01	p38 MAP kinase, IC₅₀: 6.7 nM						99.86%
RWJ-67657		p38α, IC₅₀: 1 μM	p38β, IC₅₀: 11 μM				99.75%
JNJ-49095397		p38α				p38γ	99.85%
SJFα		p38α, DC₅₀: 7.16 nM			p38δ, DC₅₀: 299 nM		99.61%
Rotundic acid	p38 MAPK						99.41%
p38α inhibitor 2		p38α MAPK, pIC₅₀: 9.6					98.03%
Anti-inflammatory agent 35	p38 MAPK						99.77%
p38 MAP Kinase Inhibitor III	p38 MAP kinase, IC₅₀: 0.9 μM						98.77%
SD-169		p38α MAPK, IC₅₀: 3.2 nM	p38β MAPK, IC₅₀: 122 nM				99.91%
PF-05381941		p38α, IC₅₀: 186 nM					99.73%
p38 MAP Kinase Inhibitor IV		p38α, IC₅₀: 0.13 μM	p38β, IC₅₀: 0.55 μM		p38δ, IC₅₀: 8.63 μM		98.0%
AMG-548		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM	≥99.0%
SB 220025	p38, IC₅₀: 60 nM						99.90%
p38 MAPK-IN-4	p38, IC₅₀: 35 nM						98.45%
p38α inhibitor 1		p38α					98.91%
AL 8697		p38α, IC₅₀: 6 nM	p38β, IC₅₀: 82 nM				99.83%
Emprumapimod hydrochloride		p38α					≥98.0%
SX 011		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM		p38δ, IC₅₀: > 300 (Pan)	p38γ, IC₅₀: > 300 (Pan)	99.33%
NR-11c		p38α					99.75%
Sugiol	p38 MAPK						99.88%
MW-150 hydrochloride		p38α, Ki: 101 nM
MW-150 dihydrochloride dihydrate		p38α, Ki: 101 nM
Ralimetinib		p38α MAPK, IC₅₀: 5.3 nM	p38β MAPK, IC₅₀: 3.2 nM
Talmapimod hydrochloride		p38α, IC₅₀: 9 nM	p38β, IC₅₀: 90 nM
Casein kinase 1δ-IN-27		p38α, IC₅₀: 14.8 nM
p38-α MAPK-IN-4		p38α MAPK, IC₅₀: 1.5 μM
Casein kinase 1δ-IN-29		p38α, IC₅₀: 0.041 μM
Halociline	p38 MAP kinase
SJFδ		p38α, DC₅₀: 46.17 nM
p38-α MAPK-IN-5		p38α, IC₅₀: 0.1 nM	p38β, IC₅₀: 0.2 nM		p38δ, IC₅₀: 4100 nM	p38γ, IC₅₀: 944 nM
p38 MAPK-IN-3		p38α MAPK
SB-284851-BT		p38α, Kd: 0.47 nM
J-1149		p38α MAPK
p38α inhibitor 7		p38α
MW108 hydrochloride		p38α MAPK, Ki: 114 nM
p38α-MK2-IN-1		p38α
DCZ19931	p38 MAPK
Lucidone	p38 MAPK
AMG-548 hydrochloride		p38α, Ki: 0.5 nM dog p38α, Ki: 5.0 nM	p38β, Ki: 3.6 nM		p38δ, Ki: 2600 nM	p38γ, Ki: 4100 nM
CHMFL-ABL-053	p38, IC₅₀: 62 nM
Semapimod	p38 MAPK
NDs-IN-1	p38 MAPK
(aS)-PH-797804		p38α, IC₅₀: 26 nM	p38β, IC₅₀: 102 nM
JNK3 inhibitor-5		p38α, IC₅₀: 215.8 nM
Balanophonin	p38
Doramapimod (GMP)		p38α, IC₅₀: 38 nM	p38β, IC₅₀: 65 nM		p38δ, IC₅₀: 520 nM	p38γ, IC₅₀: 200 nM
PF-03715455		p38α, IC₅₀: 0.88 nM	p38β, IC₅₀: 23 nM
SR-302		p38α, IC₅₀: 125 nM
BMS-582949		p38α, IC₅₀: 13 nM
CK1δ-IN-9		p38α, IC₅₀: 0.25 μM	p38β, IC₅₀: 0.78 μM
Cudraflavone B	p38 MAP kinase
p38α inhibitor 4		p38α, IC₅₀: 1.2 μM
Casein kinase 1δ-IN-31		p38α, IC₅₀: 18 nM
p38α inhibitor 8		p38α, IC₅₀: 0.21 μM
p38-α MAPK-IN-10		p38α, IC₅₀: 4 nM

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p38 MAPK

p38 MAPK

p38 MAPK Isoform Specific Products:

p38 MAPK Isoform Specific Products:

p38 MAPK Related Products (530)

Recombinant Proteins (3)

Antibodies (20)

p38 MAPK Isoform Comparison

p38 MAPK Related Products (530):